Scientific Publications

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Research Associate and Core Manager
Houston Methodist Research Institute
Genomic Medicine
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Quintela M, Sieglaff DH, Gazze AS, Zhang A, Gonzalez D, Francis L, Webb P, Conlan RS. 2019. HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine. 2019 Apr;17:254-265. doi: 10.1016/j.nano.2019.01.017. Epub 2019

Zhao W, Beers DR, Hooten KG, Sieglaff DH, Zhang A, Kalyana-Sundaram S, Traini CM, Halsey WS, Hughes AM, Sathe GM, Livi GP, Fan GH, Appel SH. 2017. Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes. JAMA Neurol. 2017 Jun 1;74(6):677-685. doi: 10.1001/jamaneurol.2017.0357

da Silva Teixeira S, Filgueira C, Sieglaff DH, Benod C, Villagomez R, Minze LJ, Zhang A, Webb P, Nunes MT. 3,5-diiodothyronine (3,5-T2) reduces blood glucose independently of insulin sensitization in obese mice. Acta Physiol (Oxf). 2017 Jun;220(2):238-250. doi: 10.1111/apha.12821

Dave B, Gonzalez DD, Liu ZB, Li X, Wong H, Granados S, Ezzedine NE, Sieglaff DH, Ensor JE, Miller KD, Radovich M, KarinaEtrovic A, Gross SS, Elemento O, Mills GB, Gilcrease MZ, Chang JC. Role of RPL39 in Metaplastic Breast Cancer. J Natl Cancer Inst. 2016 Dec 31;109(6):djw292. doi: 10.1093/jnci/djw292.

Cvoro A, Bajic A, Zhang A, Simon M, Golic I, Sieglaff DH, Maletic-Savatic M, Korac A, Webb P. Ligand Independent and Subtype-Selective Actions of Thyroid Hormone Receptors in Human Adipose Derived Stem Cells. PLoS One. 2016 Oct 12;11(10):e0164407. doi: 10.1371/journal.pone.0164407

Puhl AC, Milton FA, Cvoro A, Sieglaff DH, Campos JC, Bernardes A, Filgueira CS, Lindemann JL, Deng T, Neves FA, Polikarpov I, Webb P. Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti- inflammatory drugs. Nucl Recept Signal. 2015 Oct 5;13:e004. doi: 10.1621/nrs.13004

Suh JH, Chattopadhyay A, Sieglaff DH, Storer Samaniego C, Cox MB, Webb P. Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists. PLoS One. 2015 Sep 2;10(9):e0137103. doi: 10.1371/journal.pone.0137103

Milton FA, Cvoro A, Amato AA, Sieglaff DH, Filgueira CS, Arumanayagam AS, de Lima Mdo C, Pitta IR, de Assis Rocha Neves F, Webb P. PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2015 Aug 28;464(3):718-23. doi: 10.1016/j.bbrc.2015.07.011. Epub 2015 Jul 10

Zhang A, Sieglaff DH, York JP, Suh JH, Ayers SD, Winnier GE, Kharitonenkov A, Pin C, Zhang P, Webb P, Xia X. Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver. J Endocrinol. 2015 Mar;224(3):289-301. doi: 10.1530/JOE-14-0440. Epub 2014 Dec 11

Cvoro A, Devito L, Milton FA, Noli L, Zhang A, Filippi C, Sakai K, Suh JH, Sieglaff DH, Dhawan A, Sakai T, Ilic D, Webb P. A thyroid hormone receptor/KLF9axis in human hepatocytes and pluripotent stem cells. Stem Cells. 2015 Feb;33(2):416-28. doi: 10.1002/stem.1875

Lin JZ, Sieglaff DH, Yuan C, Su J, Arumanayagam AS, Firouzbakht S, Cantu Pompa JJ, Reynolds FD, Zhou X, Cvoro A, Webb P. Gene specific actions of thyroid hormone receptor subtypes. PLoS One. 2013;8(1):e52407. doi: 10.1371/journal.pone.0052407. Epub 2013 Jan 3

Suh JH, Sieglaff DH, Zhang A, Xia X, Cvoro A, Winnier GE, Webb P. SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions. PLoS One. 2013 Jul 26;8(7):e70097. doi: 10.1371/journal.pone.0070097

Yuan C, Lin JZ, Sieglaff DH, Ayers SD, Denoto-Reynolds F, Baxter JD, Webb P. Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology. 2012 Jan;153(1):501-11. doi: 10.1210/en.2011-1325. Epub 2011 Nov 8

Deng T, Sieglaff DH, Zhang A, Lyon CJ, Ayers SD, Cvoro A, Gupte AA, Xia X, Baxter JD, Webb P, Hsueh WA. A peroxisome proliferator-activated receptor gamma (PPARgamma)/PPARgamma coactivator 1beta autoregulatory loop in adipocyte mitochondrial function. J Biol Chem. 2011 Sep 2;286(35):30723-30731. doi: 10.1074/jbc.M111.251926. Epub 2011 Jun 30

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Postdoctoral Fellow in Biomedical Informatics
University of California, Irvine
Institute for Genomics and Bioinformatics
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Sieglaff DH, Dunn WA, Xie XS, Megy K, Marinotti O, James AA. Comparative genomics allows the discovery of cis-regulatory elements in mosquitoes. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3053-8. doi: 10.1073/pnas.0813264106. Epub 2009 Feb 11

Terenius O, Marinotti O, Sieglaff D, James AA. Molecular genetic manipulation of vector mosquitoes. Cell Host Microbe. 2008 Nov 13;4(5):417-23. doi: 10.1016/j.chom.2008.09.002

Wu J, Sieglaff DH, Gervin J, Xie XS. Discovering regulatory motifs in the Plasmodium genome using comparative genomics. Bioinformatics. 2008 Sep 1;24(17):1843-9. doi: 10.1093/bioinformatics/btn348. Epub 2008 Jul 8

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Postdoctoral Scholar
University of California, Riverside
Institute for Integrative Genome Biology
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Cruz J, Sieglaff DH, Arensburger P, Atkinson PW, Raikhel AS. Nuclear receptors in the mosquito Aedes aegypti: annotation, hormonal regulation and expression profiling. FEBS J. 2009 Mar;276(5):1233-54. doi: 10.1111/j.1742-4658.2008.06860.x

Shiao SH, Hansen IA, Zhu J, Sieglaff DH, Raikhel AS. Juvenile hormone connects larval nutrition with target of rapamycin signaling in the mosquito Aedes aegypti. J Insect Physiol. 2008 Jan;54(1):231-9. doi: 10.1016/j.jinsphys.2007.09.007. Epub 2007 Oct 2

Hansen IA, Sieglaff DH, Munro JB, Shiao SH, Cruz J, Lee IW, Heraty JM, Raikhel AS. Forkhead transcription factors regulate mosquito reproduction. Insect Biochem Mol Biol. 2007 Sep;37(9):985-97. doi: 10.1016/j.ibmb.2007.05.008. Epub 2007 May 24

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Graduate Student
University of Georgia
Department of Entomology
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Brown MR, Sieglaff DH, Rees HH. Gonadal ecdysteroidogenesis in arthropoda: occurrence and regulation. Annu Rev Entomol. 2009;54:105-25. doi: 10.1146/annurev.ento.53.103106.093334

Sieglaff DH, Duncan KA, Brown MR. Expression of genes encoding proteins involved in ecdysteroidogenesis in the female mosquito, Aedes aegypti. Insect Biochem Mol Biol. 2005 May;35(5):471-90. doi: 10.1016/j.ibmb.2005.01.011. Erratum in: Insect Biochem Mol Biol. 2005 Nov;35(11):1310

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